Protein Details: Aquaporin-3

Protein ID

ICDB_Pro_0531

Protein Name

Aquaporin-3

Gene Name

AQY3; YFL054C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Bakers yeast)

Length

646 amino acids

AlphaFoldDB

AF-P43549-F1-model_v4.pdb

Function

Channel protein that mediates glycerol entry under ethanol stimulation . Does not seem to mediate glycerol uptake under standard conditions .

Sequence

MSYESGRSSSSSESTRPPTLKEEPNGKIAWEESVKKSRENNENDSTLLRRKLGETRKAIETGGSSRNKLSALTPLKKVVDERKDSVQPQVPSMGFTYSLPNLKTLNSFSDAEQARIMQDYLSRGVNQGNSNNYVDPLYRQLNPTMGSSRNRPVWSLNQPLPHVLDRGLAAKMIQKNMDARSRASSRRGSTDISRGGSTTSVKDWKRLLRGAAPGKKLGDIEAQTQRDNTVGADVKPTKLEPENPQKPSNTHIENVSRKKKRTSHNVNFSLGDESYASSIADAESRKLKNMQTLDGSTPVYTKLPEELIEEENKSTSALDGNEIGASEDEDADIMTFPNFWAKIRYHMREPFAEFLGTLVLVIFGVGGNLQATVTKGSGGSYESLSFAWGFGCMLGVYVAGGISGGHINPAVTISMAIFRKFPWKKVPVYIVAQIIGAYFGGAMAYGYFWSSITEFEGGPHIRTTATGACLFTDPKSYVTWRNAFFDEFIGASILVGCLMALLDDSNAPPGNGMTALIIGFLVAAIGMALGYQTSFTINPARDLGPRIFASMIGYGPHAFHLTHWWWTWGAWGGPIAGGIAGALIYDIFIFTGCESPVNYPDNGYIENRVGKLLHAEFHQNDGTVSDESGVNSNSNTGSKKSVPTSS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1038/ng0795-261; 10.1534/g3.113.008995; 10.1101/gr.6037607; 10.1074/jbc.273.42.27565; 10.1016/s0005-2736(03)00138-x; 10.1073/pnas.0604075103; 10.1074/mcp.m700468-mcp200

RefSeq

NP_116601.1